Jennewein Biotechnologie

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15.12.2014 Toxicology & Safety : A 3-week pre-clinical study of the human milk oligosaccharide 2′-Fucosyllactose in farm piglets

Publication of Toxicology & Safety Study on 2′-Fucosyllactose

One of the most abundant oligosaccharides found in human milk is 2′-Fucosyllactose, a trisaccharide composed of fucose and lactose, and multiple studies have demonstrated a health benefit to this compound.

A neonatal piglet model was used to evaluate the tolerability of 2′-Fucosyllactose, produced by fermentation, in order to demonstrate the suitability of this compound for human infants under 12 weeks of age. Crossbred farm piglets, at lactation day 2, were assigned to one of four treatment groups receiving a liquid diet containing 0, 200, 500 or 2000 mg/L of 2′-Fucosyllactose.

Piglets were administered diet for 3 weeks; and there were no test article-related effects on growth and development, clinical pathology parameters, or any histopathologic changes. Therefore, dietary exposure to 2′-Fucosyllactose at concentrations up to 2000 mg/L was well tolerated by neonatal farm piglets and did not result in adverse health effects or impact piglet growth.

For details please see scientific publication.