Saccharides play a key role in cellular identity. In humans, L-Fucose and Sialic acid (also known as N-acetylneuraminic acid) are often used as the terminal saccharides of glycans displayed on the cell surface, therefore providing a cellular fingerprint.
These glycan structures play numerous roles in the body, e.g. they are involved in the recognition of human cells by bacterial and viral pathogens as well as mediating the resulting immune response, they act as determinants of the ABO blood group system, and abnormal glycan structures are associated with diseases such as cancer, psoriasis or the rare genetic disorder leukocyte adhesion deficiency II (LAD II). Because L-Fucose and Sialic acid are often found in the glycans on human cells, these sugar molecules offer promising applications as the active ingredients of prophylactic and therapeutic pharmaceutical products.
Jennewein Biotechnologie has developed innovative production processes for the efficient and scalable manufacture of highly pure forms of L-Fucose and Sialic-acid. These processes, and the production capacity we have established, allow these monosaccharides to be used in numerous applications, such as the manufacture of pharmaceutical products, or as ingredients in cosmetics and therapeutic animal feed.