Scientific References - Jennewein Biotechnologie GmbH

Human Milk Oligosaccharides in General

Bienenstock, J. et al. (2013) PLoS One	Fucosylated but not sialylated milk oligosaccharides diminish colon motor contractions
Bode, L., (2012) Glycobiology	Human milk oligosaccharides: every baby needs a sugar mama
Bode, L., et al. (2012) Advances in Nutrition	Structure-function relationship of human milk oligosaccharides
Bode, L. (2006) Journal of Nutrition	Recent advances on structure, metabolism, and function of human milk oligosaccharides
Boehm, G., et al. (2007) British Journal of Nutrition	Oligosaccharides from milk
Brand Miller, J. (1999) Nutrition Reviews	Human milk oligosaccharides: 130 reasons to breast-feed
Bruggencate, S. et al. (2014) Nutrition Reviews	Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides
Castanys-Munoz, E., et al. (2013) Nutrition Reviews	2’-Fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
Coppa, G. V., et al. (1999) Acta Paediatric Supply	Oligosaccharides in human milk during different phases of lactation
Goehring, K. C., et al. (2014) PLoS One	Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants
Hanlon, P. R., et al. (2014) Food and Chemical Toxicology	A 3-week pre-clinical study of 2’-Fucosyllactose in farm piglets
Hennet, T., et al. (2014) Swiss Medical Weekly	Decoding breast milk oligosaccharides
Holmlund, U., et al. (2010) Clinical and Experimental Immunology	Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring
Jantscher-Krenn, E., et al. (2012) Minerva Pediatrica	Human milk oligosaccharides and their potential benefits for the breast-fed neonate
Kunz, C., (2012) Advances in Nutrition	Historical aspects of human milk oligosaccharides
Kunz, C., et al. (2006) International Dairy Journal	Health promoting aspects of milk oligosaccharides
Marx, C., et al. (2014) Journal of Human Lactation	Human milk oligosaccharide composition differs between donor milk and mother’s own milk in NICU
Morrow, A. L., et al. (2011) The Journal of Pediatrics	Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants
Nakhla, T., et al. (1999) British Journal of Nutrition	Neutral oligosaccharide content of preterm human milk
Newburg, D. S. (2013) Biochemistry	Glycobiology of human milk
Obermeier, S., et al. (1999) Isotopes Environ Health Study	Secretion of 13C-labelled oligosaccharides into human milk and infant's urine after an oral [13C]galactose load
Oriquat, G. A. (2011) American Journal of Biochemistry and Biotechnology	Soluble CD14, sialic acid and L-Fucose in breast milk and their role in increasing the immunity of breast-fed infants
Rudloff, S., et al. (2012) Advances in Nutrition	Milk oligosaccharides and metabolism in infants
Sabharwal, H., et al. (1991) Journal of Pediatric Gastroenterology and Nutrition	Sialylated oligosaccharides in human milk and feces of preterm, full-term, and weaning infants
Schauer, R. (2004) Zoology	Sialic acids: fascinating sugars in higher animals and man
Thurl, S., et al. (2010) British Journal of Nutrition	Variation of human milk oligosaccharides in relation to milk groups and lactational periods
Urashima, T., et al. (2012) Advances in Nutrition	The predominance of type I oligosaccharides is a feature specific to human breast milk
Urashima, T., et al. (2012) Animal	Evolution of milk oligosaccharides and lactose: a hypothesis
Vos, A. P. (2007) Pediatric Allergy Immunology	Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice

Prebiotic Effects of HMOs

Bode, L. (2009) Nutrition Reviews	Human milk oligosaccharides: prebiotics and beyond
Chow, J., et al. (2014) Journal of Proteome Research	Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation
Coppa, G. V., et al. (2006) Digestive & Liver Disease	Prebiotics in human milk : a review
Coppa, G. V., et al. (2004) Journal of Clinical Gastroenterology	The first prebiotics in humans: human milk oligosaccharides
Dotz, V., et al. (2015) Molecular Nutrition & Food Research	Metabolic fate of neutral human milk oligosaccharides in exclusively breast-fed infants
Erney, R. M., et al. (2000) Journal of Pediatric Gastroenterology and Nutrition	Variability of human milk neutral oligosaccharides in a diverse population
Fuhrer, A., et al. (2010) Journal of Experimental Medicine	Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization
Gnoth, M. J., et al. (2000) Journal of Nutrition	Human milk oligosaccharides are minimally digested in vitro
Harmsen, H. J., et al. (2000) Journal of Pediatric Gastroenterology & Nutrition	Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods
Jeong, K., et al. (2012) BMB Reports	Human milk oligosaccharides: the novel modulator of intestinal microbiota
Kurakevich, E., et al. (2013) Proceedings of the National Academy of Science of the USA	Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4
Li, M., et al. (2012) Journal of Nutrition	Microbial Composition and in vitro fermentation patterns of human milk oligosaccharides and prebiotics differ between formula-fed and sow-reared piglets
Newburg, D. S. (2000) Journal of Pediatric Gastroenterology & Nutrition	Oligosaccharides in human milk and bacterial colonization
Moro, G., et al. (2006) Archives of Disease in Childhood	A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age
Pacheco, A.R., et al. (2015) Annual Review of Animal Biosciences	The impact of the milk glycobiome on the neonate gut microbiota
Satoh, T., et al. (2013) Anaerobe	In vitro comparative evaluation of the impact of lacto-N-biose I, a mojor building block of human milk oligosaccharides, on the fecal microbiota of infants
Wang, M., et al. (2015) Journal of Pediatric Gastroenterology & Nutrition	Fecal Microbiota Composition of Breast-fed Infants is Correlated with Human Milk Oligosaccharides Consumed
Weiss, G. A., et al. (2014) British Journal of Nutrition	Selective proliferation of intestinal Barnesiella under fucosyllactose supplementation in mice
Weiss, G. A., et al. (2012) Advances in Nutrition	The role of milk sialyllactose in intestinal bacterial colonization
Yoshioka, H., et al. (1983) Pediatrics	Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants
Yu, Z. T., et al. (2013) Glycobiology	Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes
Yu, Z. T., et al. (2012) Glycobiology	The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant micobiota
Zivkovic, A. M., et al. (2010) Proceedings of the National Academy of Science of the USA	Human milk glycobiome and its impact on the infant gastrointestinal microbiota

Reducing Infection and Inflammation Risks by HMOs

Cilieborg, M. (2012)	A milk oligosaccharides, 2’-fucosyllactose, may ameliorate necrotizing enterocolitis in preterm pigs
Coppa, G. V., et al. (2006) Pediatric Research	Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris
Crane, J. K., et al. (1994) Journal of Nutrition	Oligosaccharides from human milk block binding and activity of the Escherichia coli heat-stable enterotoxin (STa) in T84 intestinal cells
He, Y., et al. (2015) Gut	The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation
Hester, S. N., et al. (2013) British Journal of Nutrition	Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets
Hickey, R. (2012) International Dairy Journal	The role of oligosaccharides from human milk and other sources in prevention of pathogen adhesion
Hong, P. et al. (2009) British Journal of Nutrition	Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin
Jantscher-Krenn, E., et al. (2013) Gut	The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats
Jantscher-Krenn, E., et al. (2012) British Journal of Nutrition	Human milk oligosaccharides reduces Entamoeba histolytica attachment and cytotoxicity in vitro
Kuhn, L., et al. (2015) Journal of Nutrition	Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia
Kunz, C., et al. (2008) Advances in Experimental Medicine & Biology	Potential anti-inflamatory and anti-infectious effects of human milk oligosaccharides
Li, M., et al. (2014) ISME Journal	Human milk oligosaccharides shorten rotavirus-induced diarrhea and modulate piglet mucosal immunity and colonic microbiota
Manthey, C. F., et al. (2014) Journal of Pediatric Gastroenterology & Nutrition	Human milk oligosaccharides protect against enteropathogenic Eschericia coli attachment in vitro and EPEC colonization in suckling mice
Morrow, A. L., et al. (2005) Journal of Nutrition	Human milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea
Morrow, A. L., et al. (2004) Journal of Pediatrics	Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
Morrow, A. L., et al. (2004) Journal of Pediatrics	Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
Newburg, D. S., et al. (2005) Annual Review of Nutrition	Human milk glycans protect infants against enteric pathogens
Newburg, D. S., et al. (2003) Glycobiology	Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
Ruiz-Palacios, G. M., et al. (2003) Journal of Biological Chemistry	Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha-1,2Gal beta1,4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection
Stepans, M. B., et al. (2006) Breastfeeding Medicine	Early consumption of human milk oligosaccharides is inversely related to subsequent risk of respiratory and enteric disease in infants
Van Niekerk, E., et al. (2014) Journal of Nutrition	Human Milk Oligosaccharides differ between HIV-infected and HIV-uninfected mothers and are related to Necrotizing Enterocolitis incidence in their preterm very-low-birth-weight infants
Weichert, S., et al. (2013) Nutrition Research	Bioengineered 2’-Fucosyllactose and 3-Fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines

Supporting Brain Development and Neuronal Function by HMOs

Ducan, P. I., et al. (2009) PLoS One	Sialic acid utilisation and synthesis in the neonatal rat revisited
Karim, M., et al. (2006) CAB Reviews	Is sialic acid in milk food for the brain?
Margolis, R. U., et al. (1975) Biochemistry	Glycosaminoglycans of brain during development
Rutishauser, U. (2008) Nature Reviews: Neuroscience	Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Sprenger, N., et al. (2012) Advances in Nutrition	Sialic acid utilization
Sprenger, N., et al. (2009) Glycobiology	Sialic acid feeding aged rats rejuvenates stimulated salivation and colon enteric neuron chemotypes
Vázquez, E., et al. (2015) Journal of Nutritional Biochemistry	Effects of a human milk oligosaccharide, 2'-Fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
Wang, B. (2012) Advances in Nutrition	Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient for brain development and cognition
Wang, B. (2009) Annual Review of Nutrition	Sialic acid is an essential nutrient for brain development and cognition
Wang, B. (2007) American Journal of Clinical Nutrition	Dietary sialic acid supplementation improves learning and memory in piglets
Wang, B., et al. (2003) European Journal of Clinical Nutrition	The role and potential of sialic acid in human nutrition
Wang, B., et al. (2003) American Journal of Clinical Nutrition	Brain ganglioside and glycoprotein sialic acid in breastfed compared with formula-fed infants