Human Milk Oligosaccharides

Lacto-N-triose II (LNT-II)

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The neutral HMO trisaccharide Lacto-N-triose II (LNT-II) is a minor component of human breast milk. The trisaccharide LNT-II can be metabolized in the gut by Lactobacillus casei, which is considered to be a beneficial probiotic strain for humans 1,2. Although the LNT-II concentration in breast milk is rather low, the availability of the trisaccharide in the gut is even higher due to enzymatic degradation of more complex HMOs by bacterial extracellular enzymes 3.

 

At Jennewein Biotechnologie, LNT II is presently undergoing development.

 


References:

  1. Bidart, Gonzalo N., Jesús Rodríguez-Díaz, and María J. Yebra. “The extracellular wall-bound β-N-acetylglucosaminidase from Lactobacillus casei is involved in the metabolism of the human milk oligosaccharide lacto-N-triose.” Environ. Microbiol. 82.2 (2016): 570-577.
  2. Turroni, Francesca, et al. “Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective.” Cellular and Molecular Life Sciences2 (2014): 183-203.
  3. Gotoh, Aina, et al. “Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum.” Scientific reports1 (2018): 1-14.