Human Milk Oligosaccharides

Lacto-N-tetraose (LNT)

Please contact us for further details including product samples:

Human Milk Oligosaccharide LNT (Lacto-N-tetraose) is a highly abundant neutral HMO in human milk. LNT occurs in human milk at a concentration of 1.1 (± 0.36) g/L 1,2. The nitrogen-containing LNT is one of the most important prebiotics in human milk and is used to selectively stimulate the growth of desirable bifidobacteria and thus contributes significantly to the development of a natural microbiome in the newborn 3,4. In addition, LNT was shown to exhibit an anti-inflammatory effect 5. Additional functional benefits of LNT also include reducing infection by inhibiting the adhesion of pathogenic bacteria, e.g. Pseudomonas pneumoniae 6, and by binding of pathogens toxins, e.g. from Clostridium difficile 7. Growth of pathogenic Streptococci was shown to be reduced upon addition of the neutral HMO 8.

Jennewein Biotechnologie produces LNT on a commercial scale under FSSC 22000 and ISO 9001. The product is available as a spray-dried powder. Jennewein LNT product is Kosher (Orthodox Union) as well as Halal (Halal Food Council of Europe) certified.

We offer LNT (CAS 14116-68-8) with the following specification:

Product code:
1041 Lacto-N-tetraose Infant formula grade ≥ 75 % (spray-dried powder)

 

Regulatory Applications for LNT have already been filed in the EU (EFSA), and the US (FDA GRAS) and further major markets.

Please contact us for further details including product samples:

 


  1. Thurl, Stephan, et al. “Systematic review of the concentrations of oligosaccharides in human milk.” Nutrition reviews 75.11 (2017): 920-933.
  2. McGuire, Michelle K., et al. “What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically.” The American journal of clinical nutrition 105.5 (2017): 1086-1100.
  3. Bode, Lars. “Human milk oligosaccharides: prebiotics and beyond.” Nutrition reviews 67.suppl_2 (2009): S183-S191.
  4. Gotoh, Aina, et al. “Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum.” Scientific reports 8.1 (2018): 1-14.
  5. Özcan, Ezgi, and David A. Sela. “Inefficient metabolism of the human milk oligosaccharides lacto-N-tetraose and lacto-N-neotetraose shifts Bifidobacterium longum subsp. infantis physiology.” Frontiers in Nutrition 5 (2018): 46.
  6. Craft, Kelly M., and Steven D. Townsend. “The human milk glycome as a defense against infectious diseases: rationale, challenges, and opportunities.” ACS infectious diseases 4.2 (2018): 77-83.
  7. El-Hawiet, Amr, Elena N. Kitova, and John S. Klassen. “Recognition of human milk oligosaccharides by bacterial exotoxins.” Glycobiology 25.8 (2015): 845-854.
  8. Lin, Ann E., et al. “Human milk oligosaccharides inhibit growth of group B Streptococcus.” Journal of Biological Chemistry 292.27 (2017): 11243-11249.