Human Milk Oligosaccharides

Lacto-N-neotetraose (LNnT)

Please contact us for further details:

Lacto-N-neotetraose (LNnT) is a naturally occurring tetra-saccharide that belongs to the group of non-fucosyllated neutral human milk oligosaccharides (HMOs). The concentration of LNnT starts with about 0.54 g pro l in colostrum and decreases to 0,2 g/l in mature milk (Erney, 2000).


LNnT has been shown to increase the growth of beneficial gut microbiota like bifidobacteria and lactobacilli in preclinical studies: B. infantis, B. breve, L. acidophilus, L. plantarum and L. reuterii are able to utilise LNnT as substrates (Yu et al., 2013; Thongaram et al., 2014). HMOs have also been suggested to protect against important systemic infections of the newborn. For instance, LNnT reduces Streptococcus (S.) pneumoniae load in lungs in a rabbit model (Idänpään-Heikkilä et al., 1997). More recently, a randomized clinical trial demonstrated that infant formula supplemented with 2′-FL and LNnT is safe and well-tolerated. Furthermore, infants consuming a formula with 2′-FL and LNnT had significantly fewer parental reports of bronchitis, reduced incidence of lower respiratory tract infections, reduced use of antipyretics and reduced use of antibiotics compared to infants fed a formula without HMOs (Puccio et al., 2017)


Please contact us for further details: