Human Milk Oligosaccharides

Lacto-N-fucopentaose I (LNFP I)

Please contact us for further details:

Human Milk Oligosaccharide LNFP I (Lacto-N-fucopentaose I) is a highly abundant, α1-2 fucosylated HMO found in human milk. LNFP I occurs in human milk in a concentration from 1.08 to 1.53 g/L1. The specific functional benefits of LNFP I include the reduction of infections by inhibiting the adhesion of pathogenic bacteria, e.g. Escherichia coli (EPEC, UPEC) and Norovirus, and also by the binding of pathogens toxins, e.g. from Clostridium difficile2,3. In addition, a probable involvement in modulating the immune system is reported for LNFP I, and an effect on intestinal health by selective stimulation of useful bifidobacteria is also suggested4,5.

At Jennewein Biotechnologie, LNFP I is presently undergoing development.

 


Referenzen:

  1. Thurl, Stephan, et al. “Systematic review of the concentrations of oligosaccharides in human milk.” Nutrition reviews, 75.11 (2017): 920-933
  2. Derya, Sami M., et al. “Biotechnologically produced fucosylated oligosaccharides inhibit the binding of human noroviruses to their natural receptors.” Journal of Biotechnology 318 (2020):31-38.
  3. Craft, Kelly M., and Steven D. Townsend. “The human milk glycome as a defense against infectious diseases: rationale, challenges, and opportunities.” ACS infectious diseases,2 (2017): 77-83.
  4. Sotgiu et al. “Immunomodulation of Fucosyl-Lactose and Lacto-N-Fucopentaose on Mononuclear Cells from Multiple Sclerosis and Healthy Subjects.” J. Biomed. Sci., 2 (2006): 114–120.
  5. Gotoh, Aina, et al. “Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum.” Scientific reports,1 (2018): 1-14.