Human Milk Oligosaccharides

Difucosyllactose (DiFL)

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The fucosylated HMO Difucosyllactose (DiFL) occurs with a concentration of 0.33 (± 0.17) g/l in human milk 1,2. Similar to the fucosyllactose trisaccharides, 2’-fucosylactose and 3-fucosyllactose, Difucosyllactose promotes the growth of Bifidobacteria, thus helping to shape the gut microbiome 3. 2-linked fucosyllactoses generally have the potential to reduce the risk of diarrhea diseases caused by either bacterial or viral pathogens. Difucosyllactose is believed to counter viral infections; due to the binding of bacterial exotoxins, difucosyllactose can also generally protect against intestinal pathogens 2,4.

Difucosyllactose

At Jennewein Biotechnologie, Difucosyllactose is presently undergoing development. Please contact us for further details: sales@jennewein-biotech.de

 


References:

  1. McGuire, Michelle K., et al. “What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically.” The American journal of clinical nutrition5 (2017): 1086-1100.
  2. Morrow, Ardythe L., et al. “Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants.” The Journal of pediatrics3 (2004): 297-303.
  3. Gotoh, Aina, et al. “Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum.” Scientific reports,1 (2018): 1-14.
  4. Amr El-Hawiet, Elena N Kitova, John S Klassen, “Recognition of human milk oligosaccharides by bacterial exotoxins”. Glycobiology, 25.8 (2015): 845–854.