Humane Milcholigosaccharide


Jennewein Biotechnolgie has successfully established the industrial production of the five most important human milk oligosaccharides (HMOs) and thus launched its next product generation, the 5HMO-Mix. The 5HMO-Mix consists of the five most abundant HMOs 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL). As the first product worldwide, the HMO mix contains both neutral and acidic HMOs combining multiple positive effects of different HMOs in one product.

Table 1: Benefits of the HMO-Mix

All HMOs in the 5HMO-Mix have been reported to interfere with pathogens such as Campylobacter jejuni (2′-FL), salmonella (2′-FL, 3-FL), streptococci (LNT), noroviruses and rotaviruses (2′-FL, 3-FL, 3´-SL and 6′-SL). 1 The 5HMO-Mix promotes a natural gut microbiome by nourishing beneficial gut bacteria such as bifidobacteria, lactobacilli and bacteroides. 2, 3, 4 Furthermore, 2′-FL, 3-FL and 6′-SL promote intestinal motility and intestinal epithelial cell maturation. 5, 6 Fucosylated and sialylated HMOs also exert immunoregulatory effects. They normalize levels of cytokines and inflammation markers in non-breastfed children and balance immune responses. 7 Specifically 3′-SL and 6′-SL positively support brain development in infants by affecting cognition and regulation of neurons. In animal models, supplementation of sialyllactoses and sialic acid is associated with a better ability to learning and memory skills. 8, 9

Jennewein Biotechnologie offers HMOs not only in the greatest variety, but also at prices which allows them to be used in their natural concentrations in food products (incl. infant food formula). This innovative product generation is a milestone in bringing baby food even closer to the natural situation in breast milk.

The 5HMO-Mix is ​​produced at Jennewein Biotechnologie GmbH in an industrial scale under FSSC 22000 and ISO 9001.

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  1. Triantis V et al. Immunological Effects of Human Milk Oligosaccharides. Front Pediatr 2018; 6: 190
  2. Thurl S. et al. Systematic review of the concentrations of oligosaccharides in human milk. Nutr Rev. 2017; 75: 920-933
  3. Yu Z et al. Utilization of major fucosylated and sialyated human milk oligosaccharides by isolated human gut microbes. Glycobiology 2013; 23: 1281-1292
  4. Thongaram T et al. Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli. J Dairy Sci. 2017; 100: 7825-7833
  5. Bienenstock J et al. Fucosylated but not sialylated milk oligosaccharides diminish colon motor contractions. PLoS ONE 2013, 8: e76236
  6. Holscher et al. Human Milk Oligosaccharides Influence Intestinal Epithelial Cell Maturation In Vitro. J Pediatr Gastroenterol Nutr. 2017; 64(2):296-301
  7. Xiao et al. Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells. Eur J Immunol. 2019, 49(7):1001-1014.
  8. Wang B et al. Dietary sialic acid supplementation improves learning and memory in piglets. Am J Clin Nutr. 2007;85(2):561-9
  9. Jacobi SK et al. Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets. J Nutr. 2016;146(2):200-8.