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15.01.2015 Effects of 2′-Fucosyllactose on hippocampal long-term potentiation and learning capabilities

Publication of Abbott Nutrition on Cognitive Effects of Human Milk Oligosaccharide 2′-Fucosyllactose

HMOs are associated with functional development during early life, mainly related to immunity and intestinal health. Whether HMOs elicit a positive effect on cognitive capabilities of lactating infants remains an open question. This study evaluated the role of the most abundant HMO, 2′-fucosyllactose (2′-FL), in synaptic plasticity and learning capabilities in rodents.

Following chronic oral administration of 2′-FL, both species showed improvements in input/output curves and in long-term potentiation (LTP) evoked experimentally in alert behaving animals. This effect on LTP was related to better performance of animals in various types of learning behavioral tests. In addition, chronic administration of 2′-FL increased the expression of different molecules involved in the storage of newly acquired memories, such as the postsynaptic density protein 95, phosphorylated calcium/calmodulin-dependent kinase II and brain-derived neurotrophic factor in cortical and subcortical structures.

Taken together, the data show that dietary 2′-FL affects cognitive domains and improves learning and memory in rodents.

For details please see scientific publication.